Notice bibliographique
- Notice
Type(s) de contenu et mode(s) de consultation : Texte noté : sans médiation
Auteur(s) : Loenen, Wil A.M.
Titre(s) : Restriction enzymes [Texte imprimé] : a history / Wil A.M. Loenen,...
Publication : Cold Spring Harbor, New York : Cold Spring Harbor laboratory press, copyright 2019
Description matérielle : 1 vol. (XIV-346 p.) ; 24 cm
Note(s) : Notes bibliogr. Index
Restriction enzymes cleave DNA at specific recognition sites and have many uses in
molecular biology, genetics, and biotechnology. more than 4000 restriction enzymes
are known today, of which more than 621 are commercially available, justifying their
description by Nobel Prize winner Richard Roberts as "the workhorses of molecular
biology." This book is the first full-length history of these invaluable tools, from
their recognition in the 1950s to the flowering of their development in the 1970s
and 1980s to their ubiquitous availability today. The author has worked with restriction
enzymes throughout her career as a research scientist and came to know many of the
leaders in this field personally and professionally. She is the author of several
authoritative and widely appreciated reviews of the enzymes' biology. This book was
written with the close assistance of several of the field's pioneers, including Rich
Roberts, Stuart Linn, Tom Bickle, Steve Halford, and the late Joe Bertani. The seed
for the book was sown at a retirement party for Noreen Murray, to whom the book is
dedicated, and its roots lie in a remarkable 2013 conference at Colby Spring Harbor
Laboratory that celebrated the people and events that were vital to the field's development
Sujet(s) : Enzymes de restriction -- Histoire
Amplification génique -- Histoire
Indice(s) Dewey :
572.76 (23e éd.) = Enzymes protéolytiques (biochimie)
Identifiants, prix et caractéristiques : ISBN 9781621821052. - ISBN 1621821056 (rel.). - ISBN 9781621822721 (erroné). - ISBN
9781621822738 (erroné)
Identifiant de la notice : ark:/12148/cb46849898f
Notice n° :
FRBNF46849898
(notice reprise d'un réservoir extérieur)
Table des matières : Preface ; Abbreviations ; Introduction ; Discovery of a barrier to infection and
host-controlled variation: 1952-1953 ; Host-controlled variation is methylation and
restriction of DNA: the 1960s ; The discovery of type II restriction enzymes: the
1970s ; Expansion and cloning restriction enzymes: the 1970s and early 1980s ; The
first decade after the discovery of EcoRI: biochemistry and sequence analysis during
the 1970s and early 1980s ; Variety in mechanisms and structures of restriction enzymes:
~1982-1993 ; Crystal structures of type II restriction enzymes and discovery of the
common core of the catalytic domain: ~1993-2004 ; Improved detection methods, single-molecule
studies, and whole-genome analyses result in novel insights in structures, functions,
and applications of type I, II, III, and IV restriction enzymes: ~2004-2016 ; Summary
and conclusions ; Appendix A: The history of restriction enzymes October 19-21, 2013
meeting program ; Appendix B: Modern-day applications of restriction enzymes ; Index
; About the author.
