Notice bibliographique
- Notice
Type(s) de contenu et mode(s) de consultation : Texte noté : sans médiation
Auteur(s) : Grote, Mathias
Titre(s) : Membranes to molecular machines [Texte imprimé] : active matter and the remaking of life / Mathias Grote
Publication : Chicago : The University of Chicago press, copyright 2019
Description matérielle : 1 vol. (XVI-286 p.-[4] p. de pl.) : ill. ; 24 cm
Collection : Synthesis
Lien à la collection : Synthesis
Note(s) : Bibliogr. p. 247-270. Index
Today's science tells us that our bodies are filled with molecular machinery that
orchestrates all sorts of life processes. When we think, microscopic "channels" open
and close in our brain cell membranes; when we run, tiny "motors" spin in our muscle
cell membranes; and when we see, light operates "molecular switches" in our eyes and
nerves. A molecular-mechanical vision of life has become commonplace in both the halls
of philosophy and the offices of drug companies, where researchers are developing
"proton pump inhibitors" or medicines similar to Prozac. Membranes to Molecular Machines
explores just how late twentieth-century science came to think of our cells and bodies
this way. This story is told through the lens of membrane research, an unwritten history
at the crossroads of molecular biology, biochemistry, physiology, and the neurosciences,
that directly feeds into today's synthetic biology as well as nano- and biotechnology.
Mathias Grote shows how these sciences not only have made us think differently about
life, they have, by reworking what membranes and proteins represent in laboratories,
allowed us to manipulate life as "active matter" in new ways. Covering the science
of biological membranes in the United States and Europe from the mid-1960s to the
1990s, this book connects that history to contemporary work with optogenetics, a method
for stimulating individual neurons using light, and will enlighten and provoke anyone
interested in the intersection of chemical research and the life sciences--from practitioner
to historian to philosopher. -- Provided by publisher
Autre(s) forme(s) du titre :
- Autre forme du titre : Active matter and the remaking of life
Sujet(s) : Biologie moléculaire -- Recherche -- Histoire
Membranes (biologie) -- Recherche -- Histoire
Biotechnologie -- Recherche -- Histoire
Indice(s) Dewey :
572.8 (23e éd.) = Génétique biochimique
Identifiants, prix et caractéristiques : ISBN 9780226625157. - ISBN 022662515X (rel.). - ISBN 9780226625294 (erroné)
Identifiant de la notice : ark:/12148/cb46532603z
Notice n° :
FRBNF46532603
(notice reprise d'un réservoir extérieur)
Table des matières : Introduction : the molecular-mechanical vision of life ; Part one : Taking membranes
apart, isolating a molecular pump ; What membranes can tell a historian and philosopher
of the life sciences ; Active matter ; Part two: Remaking membranes and molecular
machines ; Synthesizing cells and molecules : mechanisms as "plug-and-play" ; Biochip
fever: life and technology in the 1980s ; Conclusion.
