Notice bibliographique
- Notice
Type(s) de contenu et mode(s) de consultation : Texte noté : électronique
Titre(s) : Functional polymers for nanomedicine [Texte électronique] / edited by Youqing Shen
Publication : Cambridge : Royal Society of Chemistry, 2013
Description matérielle : 1 online resource (xii, 318 pages)
Collection : RSC polymer chemistry series
Note(s) : Interest in the application of nanotechnology to medicine has surged in recent years
and could transform the way we diagnose, treat and prevent diseases such as cancer.
However, the clinical success of nanomedicine is limited because of problems with
toxicity and therapeutic efficacy. To overcome this it is essential to produce new
nanosystems with specific functions, which can be achieved by designing new polymers
with particular properties that can be used for nanomedicine. Functional Polymers
for Nanomedicine provides a complete overview of the different strategies for designing
polymers for nanomedicine applications. The first part of the book looks at the current
problems and direction in nanomedicine including a review of current design and targeting
of nanocarriers. The second part explores the design of polymers with different functions
including hyperbranched polymers, polymersomes, polysaccharides, polymeric micelles
and zwitterionic polymers and their applications in gene therapy and drug delivery.
This timely book is edited by a leading scientist in nanomedicine and provides a suitable
introduction and reference source for advanced undergraduates, postgraduates and academic
and industrial researchers in polymer science, nanotechnology and pharmacy interested
in materials for medical applications
Autre(s) auteur(s) : Shen, Youqing. Fonction indéterminée
Sujet(s) : Nanomédecine
Indice(s) Dewey :
620.5 (23e éd.) = Nanotechnologie
Identifiants, prix et caractéristiques : ISBN 9781849737388
Identifiant de la notice : ark:/12148/cb44672182f
Notice n° :
FRBNF44672182
(notice reprise d'un réservoir extérieur)
Table des matières : Machine generated contents note: ch. 1 Targeted Drug Delivery in Oncology: Current
Paradigm and Challenges / You Han Bae ; 1.1. Targeted Drug Delivery ; 1.1.1. Origins
of Targeted Drug Delivery ; 1.1.2. Progress in Targeted Drug Delivery ; 1.2. Current
Paradigm ; 1.3. Challenges to Current Paradigm ; 1.3.1. Challenges Present in the
Carrier ; 1.3.2. Challenges Present in the Target ; 1.4. Revolution ; References
; ch. 2 Targeted Nanomedicines: Challenges and Opportunities / Jinming Gao ; 2.1.
Introduction ; 2.2. Passive Targeting by Stealth Nanomedicines ; 2.2.1. Nanomedicine
Clearance by the Reticuloendothelial System ; 2.2.2. Tumor Penetration by Nanomedicines
; 2.3. Active Targeting by Surface-Functionalized Nanomedicines ; 2.3.1. Cancer
Specificity of Active Targeting Nanomedicines ; 2.3.2. Increased Clearance of Active
Targeting Nanomedicines ; 2.3.3. Tumor Accumulation: Passive vs. Active Targeting
Nanomedicines ; 2.4. Conclusion and Future Perspectives.
Contents note continued: Acknowledgements ; References ; ch. 3 Rational Design of
Translational Nanocarriers / Youqing Shen ; 3.1. The Three Key Elements for Translational
Nanomedicine ; 3.2. The 2R2S Capability of Nanocarriers ; 3.2.1.2R: Drug Retention
in Circulation versus Intracellular Release ; 3.2.2.2S: Stealthy in Circulation and
Tumor Penetration versus Sticky to Tumor Cells ; 3.3. The Material Excipientability
and Production Process Scale-Up Ability ; 3.4. Challenges of Rational Design for
Translational Nanomedicine ; 3.5. Conclusion ; References ; ch. 4 Functional Polymers
for Gene Delivery / Xian-Zheng Zhang ; 4.1. Introduction ; 4.2. Polyethylenimine-Based
Gene Vectors ; 4.2.1. Low-Toxicity Polyethylenimine ; 4.2.2. Cell-Targeted Polyethylenimine
; 4.2.3. Other Polyethylenimine Derivatives ; 4.3. Chitosan-Based Gene Vectors ;
4.3.1. PEI-Modified Chitosans ; 4.3.2. Cell-Targeted Chitosans ; 4.3.3. Other Chitosan
Derivatives ; 4.4. Dendrimer-Based Gene
Contents note continued: 4.4.1. Polyamidoamine Dendrimers ; 4.4.2. Polypropylenimine
Dendrimers ; 4.4.3. Poly(L-lysine) Dendrimers ; 4.5. Polypeptide Gene Vectors ;
4.5.1. Normal Peptide-Based Vectors ; 4.5.2. Cell-Penetrating Peptides ; 4.5.3.
Nuclear Localization Signal ; 4.5.4. Asp-Based Peptides ; 4.6. Other Gene Vectors
; 4.6.1. Lipid-Based Vectors ; 4.6.2. Polyallylamine ; 4.6.3. Linear Poly(amidoamine)s
; 4.6.4. Multi-layer Complexes ; 4.6.5. Polycarbonates ; 4.6.6. Nanoparticles ;
4.6.7. Other Types ; 4.7. Future Trends ; 4.7.1. Stem Cell Transfection ; 4.7.2.Combinatorial
Vectors ; 4.7.3. Virus Mimic Vectors ; 4.7.4. Therapeutic Genes ; 4.8. Conclusion
; Acknowledgements ; References ; ch. 5 Functional Hyperbranched Polymers for Drug
and Gene Delivery / Xinyuan Zhu ; 5.1. Introduction ; 5.2. Preparation of Functional
HBPs ; 5.2.1. Preparation of HBPs ; 5.2.2. Functionalization of HBPs ; 5.3. Functionality
of Delivery ; 5.3.1. Responsiveness ;
Contents note continued: 5.3.3. Imaging ; 5.3.4. Biodegradability and Biocompatibility
; 5.3.5. Multifunctionality ; 5.4. Applications in Drug and Gene Delivery ; 5.4.1.
Application as Drug Carriers ; 5.4.2. Application as Gene Vectors ; 5.5. Summary
; Acknowledgements ; References ; ch. 6 Functional Polymersomes for Controlled
Drug Delivery / Zhiyuan Zhong ; 6.1. Introduction ; 6.2. Stimuli-Responsive Polymersomes
; 6.3. Chimaeric Polymersomes ; 6.4. Biomimetic Polymersomes ; 6.5. Tumor-Targeting
Polymersomes ; 6.6. Conclusion and Perspectives ; Acknowledgements ; References
; ch. 7 Polymeric Micelle-Based Nanomedicine for siRNA Delivery / Jun Wang ; 7.1.
Introduction ; 7.2. Barriers to the Efficacy of siRNA Therapeutics ; 7.3. Polymeric
Micelles for siRNA Delivery ; 7.3.1. Polymeric Micelles Based on Amphiphilic Polymers
for siRNA Delivery ; 7.3.2. Smart Responsive Micelles for siRNA Delivery ; 7.4.
Co-delivery of siRNA and Drugs Based on Polymeric Micelles
Contents note continued: 7.5. Future Perspectives ; 7.6. Conclusion ; References
; ch. 8 Polysaccharide/Polynucleotide Complexes for Cell-Specific DNA Delivery /
Kazuo Sakurai ; 8.1. Introduction ; 8.2. Characterization of the SPG/DNA Complex
; 8.2.1. Preparation of the SPG/DNA Complex ; 8.2.2. Solution Properties and Characterization
; 8.2.3. Thermal Stability of the Complexes ; 8.3. Application of the Complex to
ODN Delivery ; 8.3.1. Uptake of the Complex by Macrophages ; 8.3.2. IL-12 Secretion
Due to Administration of Cpg-ODN/SPG Complexes ; 8.3.3. LPS-Induced TNF-[alpha] Suppression
by the AS-ODN/SPG Complex in vitro and in vivo ; 8.3.4.A New Therapy for Inflammatory
Bowel Disease Using Antisense Macrophage-Migration Inhibitory Factor ; 8.4. Conclusion
; References ; ch. 9 Design of Complex Micelles for Drug Delivery / Linqi Shi ;
9.1. Introduction ; 9.2. Core-Shell--Corona Micelles for Drug Delivery ; 9.3.Complex
Micelles with Surface Channels for Drug Delive
Contents note continued: 9.4. Polyion Complex Micelles for Drug Delivery ; References
; ch. 10 Zwitterionic Polymers for Targeted Drug Delivery / Sheng Fu Chen ; 10.1.
Introduction ; 10.2. Principles Toward Protein-Resistant Zwitterionic Polymers ;
10.3. Phosphorylcholine-Based Polymers for Drug Delivery ; 10.4. CBMA-Based Polymers
for Drug Delivery ; 10.5. Conclusion and Perspectives ; References ; ch. 11 Polymer-Based
Prodrugs for Cancer Chemotherapy / Youqing Shen ; 11.1. Introduction ; 11.2. Design
of Polymer-Based Prodrugs ; 11.2.1. Linkers ; 11.2.2. Modifiers ; 11.2.3. Drawbacks
of Current Polymer-Based Prodrugs ; 11.3. New Strategies for Polymer Prodrugs ;
11.3.1. Self-Assembling Prodrugs ; 11.3.2. Prodrug Micelles ; 11.3.3. Drug Polymers
; 11.4. Future Challenges ; References ; ch. 12 Nonviral Vector Recombinant Mesenchymal
Stem Cells: A Promising Targeted-Delivery Vehicle in Cancer Gene Therapy / Jian-Qing
Gao ; 12.1. Introduction.
Contents note continued: 12.2. Gene Recombination of MSCs ; 12.2.1. Viral Vectors
; 12.2.2. Nonviral Vectors ; 12.2.3. Three-Dimensional and Reverse Transfection
Systems ; 12.3. MSCs as a Promising Targeted-Delivery Vehicle in Cancer Gene Therapy
; 12.3.1. Rationale for Using MSCs as a Vehicle for Gene Delivery ; 12.3.2. Targeting
of MSCs to Tumor Cells ; 12.3.3. MSCs as Tumor Target Vehicles for Gene Delivery
; 12.4. Future Perspectives ; Acknowledgements ; References ; ch. 13 Near-Critical
Micellization for Nanomedicine: Enhanced Drug Loading, Reduced Burst Release / Youqing
Shen ; 13.1. Introduction ; 13.2. Early Feasibility Studies on Model Systems ;
13.3. Extension to PEG-b-PCL ; 13.4. Optimizing the NCM Solvent ; 13.5. Loading
PEG-b-PCL with a Cancer Drug ; 13.6. NCM: A Remedy for Burst Release? ; 13.7. Conclusion
and Future Research Questions ; Acknowledgements ; References.