Notice bibliographique
- Notice
Type(s) de contenu et mode(s) de consultation : Texte noté : électronique
Auteur(s) : Marín-García, José (1936-....)
Akhmedov, Alexander
Rybin, Vitalyi
Moe, Gordon W.
Titre(s) : Mitochondria and their role in cardiovascular disease [Texte électronique] / by José Marín-García ; with contributions by Alexander Akhmedov and Vitalyi Rybin, Gordon W. Moe
Publication : New York : Springer, [2013]
Description matérielle : 1 ressource dématérialisée
Note(s) : Includes bibliographical references and index
"Over the past two decades, due to dramatic advances in molecular and cell biology,
biochemistry, and genetics, our view on mitochondria as a relatively static cellular
powerhouse has changed radically. We now know that these organelles play a critical
role in the normal and in the damaged heart. Written by Dr. José Marín-García, Director
of the Molecular Cardiology and Neuromuscular Institute, Mitochondria and Their Role
in Cardiovascular Disease brings readers up- to-date on the many significant advances
in the field of mitochondrial cardiovascular medicine. The book begins with a general
introduction to mitochondria, followed by laboratory methods to study the structure
and function of the organelle, regulation of replication and biogenesis, and the mechanisms
and functional consequences of mitophagia and mitochondrial dynamics. Subsequent chapters
deal with mitochondrial oxidative stress and the role that the organelle plays in
cell signaling and cell death. Discussions will be undertaken on the biochemistry
of mitochondrial cell signaling, including the nature of the proteins engaged in these
processes, many of them only recently discovered. Later chapters examine the role
of mitochondria and mitochondrial abnormalities in cardiovascular diseases, including
their diagnosis, therapeutic options currently available, animal models of mitochondrial
disease, and new frontiers in mitochondria cardiovascular medicine, including areas
of research that are relatively new or developing, such as proteomics, next generation
sequencing, and systems biology."
Sujet(s) : Appareil cardiovasculaire -- Maladies
Mitochondriopathies
Myocarde -- Métabolisme
Indice(s) Dewey :
616.124 (23e éd.) = Myocardite (médecine)
Identifiants, prix et caractéristiques : ISBN 9781461445999
Identifiant de la notice : ark:/12148/cb44665087d
Notice n° :
FRBNF44665087
(notice reprise d'un réservoir extérieur)
Table des matières : Section I: General Principles of Mitochondria and the Heart. Introduction to Mitochondria
in the Heart ; Methods to Study Mitochondrial Structure and Function ; Mitochondrial
Structure, Composition, and Dynamics ; Mitochondrial Biogenesis ; Mechanisms of Bioenergy
Production in Mitochondria ; Bioenergetics Interplay Between Cardiac Mitochondria
and Other Subcellular Compartments. ; Section II: Heart Mitochondria Signal Transduction:
Stem Cells. Endothelial Mitochondria: Contribution to Cardiovascular Function and
Disease ; Heart Mitochondria: Receivers and Transmitters of Signals ; Stem Cells and
Mitochondria. ; Section III: Stress and Cell Death. Heart Mitochondrial ROS and Oxidative
Stress ; Cell-Death Pathways and Mitochondria. ; Section IV: Mitochondria in Pediatric
Cardiology. Mitochondria in Pediatric Cardiovascular Diseases. ; Section V: The Aging
Heart and Mitochondria. Mitochondria in the Aging Heart. ; Section VI: Mitochondria
in Atherosclerosis, Hypertension and Isch
