Notice bibliographique
- Notice
Type(s) de contenu et mode(s) de consultation : Texte noté : électronique
Titre(s) : International Review of Cell and Molecular Biology [Texte électronique] / Kwang W. Jeon, Lorenzo Galluzzi
Publication : Academic Press, 2016
Description matérielle : 1 online resource (440 pages)
Collection : International Review of Cell and Molecular Biology ; 327
Note(s) : International Review of Cell and Molecular Biology presents comprehensive reviews
and current advances in cell and molecular biology. The series has a worldwide readership,
maintaining its high standard by publishing invited articles on important and timely
topics that are authored by prominent cell and molecular biologists
Autre(s) auteur(s) : Jeon, Kwang W.. Fonction indéterminée
Galluzzi, Lorenzo. Fonction indéterminée
Sujet(s) : Cytologie
Biologie moléculaire
Identifiants, prix et caractéristiques : ISBN 9780128048054
Identifiant de la notice : ark:/12148/cb446404914
Notice n° :
FRBNF44640491
(notice reprise d'un réservoir extérieur)
Table des matières : Cover ; Title Page; Copyright Page; Contents; Contributors; Dedication; Chapter One
; Sensing the Environment Through Sestrins: Implications for Cellular Metabolism ;
Abstract; 1 Introduction; 2 Regulation and Function of Sestrins; 2.1 Regulation of
Transcription of the Sestrin Family Members; 2.1.1 DNA Damage; 2.1.2 Oxidative Stress;
2.1.3 Nutrients and Oxygen Deprivation; 2.2 Sestrins as Antioxidant Proteins: Old
Friends or New Foes?; 2.3 Sestrins are Regulators of mTOR; 2.3.1 The mTOR Complexes;
2.3.2 Regulation of mTORC1; 2.3.3 Sestrins Potentiate AMPK Activity
2.3.4 mTORC1 Regulation by the Sestrin-GATOR-Rags Axis2.3.5 Regulation of the mTORC2-Akt
Pathway by Sestrins; 2.4 Sestrins and Autophagy; 2.4.1 Regulation of Autophagy; 2.4.2
Sestrins Promote Autophagy; 3 Sestrins are Sensors of Nutrient Availability and are
Involved in Regulation of Metabolism; 3.1 Hypernutrition and Growth Factors; 3.2 Glucose;
3.3 Oxygen; 3.4 Amino Acids; 3.5 Lipids; 4 Conclusions and Perspectives; Acknowledgments;
References; Chapter Two ; Metabolic Regulation of Apoptosis in Cancer ; Abstract;
1 Introduction; 2 Overview of Apoptosis Pathways; 2.1 Caspases
2.2 Intrinsic and Extrinsic Pathways2.3 Activation of Initiator Caspases; 2.4 Mitochondria
Outer Membrane Permeabilization (MOMP); 3 Regulation of Apoptosis Through Glycolytic
Pathway; 3.1 Hypoxia-Inducible Factor-1; 3.2 AKT; 3.3 BAD; 3.4 NOXA; 3.5 Caspase-2;
3.6 Cytochrome c; 4 p53 and Glucose Metabolism; 4.1 GLUT1/GLUT4 and HK2; 4.2 TIGAR
(TP53-Induced Glycolysis and Apoptosis Regulator); 4.3 Apoptosis-Inducing Factor and
Synthesis of Cytochrome c Oxidase 2; 4.4 Glucose-6-Phosphate Dehydrogenase; 5 Regulation
of Apoptosis by Lipid Metabolism; 5.1 Introduction of Sphingolipid Pathway
5.2 Pro-apoptotic Functions of Ceramide5.3 Role of Pathways That Regulate Ceramide
Production; 5.3.1 Sphingomyelinase (SMase) Pathway; 5.3.2 De Novo Synthesis; 5.3.3
Salvage Pathway; 5.4 Fatty Acids; 6 Concluding Remarks; Acknowledgments; References;
Chapter Three ; A Mechanistic Approach to the Development of Gene Therapy for Chronic
Pain ; Abstract; 1 Introduction; 2 Basics of Gene Therapy; 2.1 Gene Transfer Mechanisms;
2.2 Various Viral Vectors and Their Characteristics; 3 Physiological Mechanisms of
Nociception/Pain
3.1 Detection and Transmission of Nociceptive Signals Through the Nervous System3.1.1
From the Periphery to the SC; 3.1.2 Transmission at the First Relay, the SC; 3.1.3
Ascending Pathways and the Supraspinal Processing of Pain; 3.2 The Modulatory Systems
of Pain Transmission; 3.2.1 Spinal Control of Pain, or the Gate-Control Theory; 3.2.2
Supraspinal Control of Pain, or the Descending Inhibitory Pathway; 4 Chronic Neuropathic
Pain; 4.1 Anatomical, Cellular, and Molecular Basis of Neuropathic Pain; 4.2 Gene
Therapy for Neuropathic Pain; 4.3 Perspectives on Gene Therapy for Neuropathic Pain
