Notice bibliographique
- Notice
Type(s) de contenu et mode(s) de consultation : Texte noté : électronique
Auteur(s) : Vodovotz, Yoram
An, Gary
Titre(s) : Translational systems biology [Texte électronique] : concepts and practice for the future of biomedical research / Yoram Vodovotz, Gary An.
Publication : Amsterdam : Academic Press, an imprint of Elsevier, cop. 2015
Description matérielle : 1 online resource
Note(s) : Online resource; title from PDF title page (EBSCO, viewed October 16, 2014).
Are we satisfied with the rate of drug development? Are we happy with the drugs that
come to market? Are we getting our money's worth in spending for basic biomedical
research? In Translational Systems Biology, Drs. Yoram Vodovotz and Gary An address
these questions by providing a foundational description the barriers facing biomedical
research today and the immediate future, and how these barriers could be overcome
through the adoption of a robust and scalable approach that will form the underpinning
of biomedical research for the future. By using a combination of essays providing
the inte
Sujet(s) : Médicaments -- Mise au point
Indice(s) Dewey :
572.802 85 (23e éd.) = Génétique biochimique - Informatique appliquée
Identifiants, prix et caractéristiques : ISBN 9780123978844
Identifiant de la notice : ark:/12148/cb44635571s
Notice n° :
FRBNF44635571
(notice reprise d'un réservoir extérieur)
Table des matières : Front Cover; Translational Systems Biology; Copyright Page; Dedication; Contents;
Preface; Acknowledgments; I. Introduction and Overview; 1.1 Interesting Times: The
Translational Dilemma and the Need for Translational Systems Biology of Inflammation;
Primary Goal: Facilitate the Translation of Basic Biomedical Research to the Implementation
of Effective Clinical Therapeut ... ; How to Approach This Book; References; II. The
Current Landscape: Where It Came From, How We Got Here, and What Is Wrong.
2.1 A Brief History of the Philosophical Basis of the Scientific Endeavor: How We
Know What We Know, and How to Know MoreModels in the Cave; Earth at the Center: A
Reasonable Mistake, and an Unreasonable Perpetuation; The Scientific Method of Francis
Bacon; Newton: The (Justifiable) Origins of Physics Envy; The Problem of Induction:
Hume's Empiricism; Logic and Its True/False Promise: Logical Positivism, Godel and
Popper; Charles Peirce Suggests Taking a Guess: The Abductive Approach; The Mapping
Problem: Back to Plato?; Suggested Additional Readings.
2.2 A Brief History of Biomedical Research up to the Molecular Biology RevolutionReference;
Suggested Additional Readings; 2.3 Biomedical Research Since the Molecular Revolution:
An Embarrassment of Riches; References; 2.4 Randomized Clinical Trials: A Bridge Too
Far?; References; 2.5 Complexity in Biomedical Research: Mysticism Versus Methods;
References; Suggested Additional Readings; 2.6 Human Nature, Politics, and Translational
Inertia; Setting the Table with Bacon; An Embarrassment of Riches; Shibboleths in
Science: The Problem with Pedigrees.
Incentives and the Professionalization of ScienceDeep Pockets, with Holes: The Pharma
Conundrum; Reference; III. Translational Systems Biology: How We Propose to Fix the
Problems of the Current Biomedical Research Landscape; 3.1 Towards Translational Systems
Biology of Inflammation; Primary Goal: Facilitate the Translation of Basic Biomedical
Research to the Implementation of Effective Clinical Therapeut ... ; References; 3.2
Dynamic Knowledge Representation and the Power of Model Making; References.
3.3 A Roadmap for a Rational Future: A Systematic Path for the Design and Implementation
of New TherapeuticsRational Evaluation of Drug Candidates: Knowing What Might Work,
and More Importantly, What Won't; In silico Clinical Trials: Crossing the "Bridge
Too Far"; From Populations to Individuals: Personalizing Medical Care; References;
IV. Tools and Implementation of Translational Systems Biology: This is How We Do It;
4.1 From Data to Knowledge in Translational Systems Biology: An Overview of Computational
Approaches Across the Scientific ...
