Notice bibliographique
- Notice
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010 .. $a 9780128099285
010 .. $a 0128099283 $z 9780128099124 $z 0128099127
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181 .0 $6 01 $a i $b xxxe
181 .. $6 02 $c txt $2 rdacontent
182 .0 $6 01 $a b
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200 1. $a The epigenetics of autoimmunity $b Texte électronique $f edited by Rongxin Zhang,...
214 .0 $a [Amsterdam] $c Elsevier $a London $c Academic press
214 .4 $d C 2018
215 .. $a 1 ressource dématérialisée
225 |. $a Translational epigenetics series $v 5
300 .. $a Notes bibliogr.
330 .. $a The Epigenetics of Autoimmunity covers a topic directly related to translational epigenetics.
Via epigenetic mechanisms, a number of internal and external environmental risk factors,
including smoking, nutrition, viral infection and the exposure to chemicals, could
exert their influence on the pathogenesis of autoimmune diseases. Such factors could
impact the epigenetic mechanisms, which, in turn, build relationship with the regulation
of gene expression, and eventually triggering immunologic events that result in instability
of immune system. Since epigenetic aberrations are known to play a key role in a long
list of human diseases, the translational significance of autoimmunity epigenetics
is very high. To bridge the gap between environmental and genetic factors, over the
past few years, great progress has been made in identifying detailed epigenetic mechanisms
for autoimmune diseases. Furthermore, with rapid advances in technological development,
high-throughput screening approaches and other novel technologies support the systematic
investigations and facilitate the epigenetic identification. This book covers autoimmunity
epigenetics from a disease-oriented perspective and several chapters are presented
that provide advances in wide-spread disorders or diseases such as systemic lupus
erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), type 1 diabetes
(T1DM), systemic sclerosis (SSc), primary SjïŽgren's syndrome (pSS) and autoimmune
thyroid diseases (AITDs). These emerging epigenetic studies provide new insights into
autoimmune diseases, raising great expectations among researchers and clinicians.
This seminal book on this topic comprehensively covers the most recent advances in
this exciting and rapidly developing new science. They might reveal not only new clinical
biomarkers for diagnosis and disease progression, but also novel targets for potential
epigenetic therapeutic treatment
410 .0 $0 45474863 $t Translational epigenetics series (Online) $v 5
676 .. $a 571.973 $v 23
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