Notice bibliographique
- Notice
Type(s) de contenu et mode(s) de consultation : Texte noté : électronique
Titre(s) : The epigenetics of autoimmunity [Texte électronique] / edited by Rongxin Zhang,...
Publication : [Amsterdam] : Elsevier ; London : Academic press, copyright 2018
Description matérielle : 1 ressource dématérialisée
Collection : Translational epigenetics series ; 5
Lien à la collection : Translational epigenetics series (Online)
Note(s) : Notes bibliogr.
The Epigenetics of Autoimmunity covers a topic directly related to translational epigenetics.
Via epigenetic mechanisms, a number of internal and external environmental risk factors,
including smoking, nutrition, viral infection and the exposure to chemicals, could
exert their influence on the pathogenesis of autoimmune diseases. Such factors could
impact the epigenetic mechanisms, which, in turn, build relationship with the regulation
of gene expression, and eventually triggering immunologic events that result in instability
of immune system. Since epigenetic aberrations are known to play a key role in a long
list of human diseases, the translational significance of autoimmunity epigenetics
is very high. To bridge the gap between environmental and genetic factors, over the
past few years, great progress has been made in identifying detailed epigenetic mechanisms
for autoimmune diseases. Furthermore, with rapid advances in technological development,
high-throughput screening approaches and other novel technologies support the systematic
investigations and facilitate the epigenetic identification. This book covers autoimmunity
epigenetics from a disease-oriented perspective and several chapters are presented
that provide advances in wide-spread disorders or diseases such as systemic lupus
erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), type 1 diabetes
(T1DM), systemic sclerosis (SSc), primary SjïŽgren's syndrome (pSS) and autoimmune
thyroid diseases (AITDs). These emerging epigenetic studies provide new insights into
autoimmune diseases, raising great expectations among researchers and clinicians.
This seminal book on this topic comprehensively covers the most recent advances in
this exciting and rapidly developing new science. They might reveal not only new clinical
biomarkers for diagnosis and disease progression, but also novel targets for potential
epigenetic therapeutic treatment
Autre(s) auteur(s) : Zhang, Rongxin. Éditeur scientifique
Sujet(s) : Autoimmunité -- Aspect moléculaire
Maladies autoimmunes -- Étiologie
Embryologie
Indice(s) Dewey :
571.973 (23e éd.) = Auto-immunité
Identifiants, prix et caractéristiques : ISBN 9780128099285. - ISBN 0128099283. - ISBN 9780128099124 (erroné). - ISBN 0128099127
(erroné)
Identifiant de la notice : ark:/12148/cb45564552v
Notice n° :
FRBNF45564552
(notice reprise d'un réservoir extérieur)
Table des matières : 1. The epigenetics of autoimmunity: an overview ; 2. Immune cell development and
epigenetics ; 3. DNA methylation and histone modifications in autoimmunity ; 4.
MicroRNA and T helper cell-mediated immune responses ; 5. Long noncoding RNAs in
the immune response ; 6. Epigenetics of systemic lupus erythematosus ; 7. Rheumatoid
arthritis and epigenetics ; 8. Epigenetic modifications in multiple sclerosis pathophysiology:
potential diagnostic and therapeutic applications ; 9. Type 1 diabetes and epigenetics
; 10. Systemic sclerosis and epigenetics ; 11. Primary Sjogren's syndrome and epigenetics
; 12. Autoimmune thyroid diseases and epigenetics ; 13. The epigenetics of primary
biliary cholangitis ; 14. Immune-mediated pulmonary disease and epigenetics ; 15.
The epigenetics of autoimmunity and epigenetic drug discovery ; 16. Treatment of
autoimmune diseases and prevention of transplant rejection and graft-versus-host disease
by regulatory T cells: the state of the art and perspectives ; 17. Noncoding RNA-targeted
therapeutics in autoimmune diseases: from bench to bedside ; 18. Future challenges
and prospects for the epigenetics of autoimmunity ; Index.
