Notice bibliographique
- Notice
Type(s) de contenu et mode(s) de consultation : Texte noté : électronique
Titre(s) : Pharmacology of itch [Texte électronique] / Alan Cowan, Gil Yosipovitch, editors
Publication : Heidelberg : Springer, cop. 2015
Description matérielle : 1 ressource dématérialisée
Collection : Handbook of experimental pharmacology ; volume 226
Note(s) : Includes bibliographical references and index
"Basic research on the pharmacology of itch has exploded in the wake of two very influential
papers that were published in Nature (2007) and Science (2009). Long overlooked as
a milder form of pain, itching has rapidly gained a new appreciation in both research
and clinical communities because of its complexity and its negative effects on the
quality of life of the distressed patients. Like pain, not all itches are the same.
Unlike pain, there are no standard drugs equivalent to aspirin and morphine. Epidemiological
studies emphasize the high incidence and economic costs of itch (pruritus). It is
the most prevalent symptom of a wide variety of allergic and inflammatory skin conditions
(e.g., psoriasis, atopic dermatitis), is associated with several systemic diseases
(e.g., chronic kidney and liver disease), and occurs in patients undergoing hemodialysis,
spinal administration of opioids, and in those suffering from AIDS. The reader will
learn about the multiple pathways for itch and their interactions with pain. The relationship
between these closely related, yet distinct sensory phenomena, will be emphasized.
Both itch and pain use several common molecules to send signals to the brain. Thus,
drugs that have been, and are being, developed as analgesics may also attenuate intractable
itch. This has been an exciting and very necessary turn of events since traditional
H-1 receptor antagonists are ineffective in blocking the pruritus associated with
kidney failure and cholestasis. The clinical chapters will provide insights into contemporary
treatment regimens for pruritus in different human scenarios"--Publisher's description
Autre(s) auteur(s) : Cowan, Alan (1942-....). Fonction indéterminée
Yosipovitch, Gil (1961-....). Fonction indéterminée
Sujet(s) : Prurits
Identifiants, prix et caractéristiques : ISBN 9783662446058
Identifiant de la notice : ark:/12148/cb447132717
Notice n° :
FRBNF44713271
(notice reprise d'un réservoir extérieur)
Table des matières : Historical background of itch ; Pruritus epidemiology and quality of life ; Neurophysiology
and itch pathways ; Neuroimaging of itch as a tool of assessment of chronic itch
and its management ; The role of the Mrgpr receptor family in itch ; Transient receptor
potential channels and itch: how deep should we scratch? ; Itch control by toll-like
receptors ; Transmission of pruriceptive signals ; Role of cytokines and chemokines
in itch ; Interactions between keratinocytes and somatosensory neurons in itch ;
Itch and its inhibition by counter stimuli ; Noradrenergic modulation of itch transmission
in the spinal cord ; Protease-activated receptors and itch ; NK-1 antagonists and
itch ; Antihistamines and itch ; Targeting itch with ligands selective for [kappa]
opioid receptors ; Neuraxial opioid-induced itch and its pharmacological antagonism
; Current topical and systemic therapies for itch ; Atopic itch in dogs: pharmacology
and modeling.
