Notice bibliographique
- Notice
Type(s) de contenu et mode(s) de consultation : Texte noté : électronique
Auteur(s) : Gage, Fred H.
Christen, Yves (1948-....)
Titre(s) : Retrotransposition, diversity and the brain [Texte électronique] / Fred H. Gage, Yves Christen, (Eds)
Publication : Berlin, Heidelberg : Springer Berlin Heidelberg : Springer e-books, 2008
Description matérielle : 1 online resource
Collection : Biomedical and Life Sciences (Springer-11642; ZDB-2-SBL)
Research and Perspectives in Neurosciences
Biomedical and Life Sciences (Springer-11642)
Note(s) : Fichier PDF.
Retroelements are ancient mobile DNA found in most organisms. Long dismissed as useless,
selfish or "junk" DNA, they were thought to be mere intracellular parasites from our
distant evolutionary past. Together with their mutant relatives, L1 sequences constitute
almost 50% of the mammalian genome. L1s can retrotranspose in a defined window of
the neuronal differentiation, changing the genetic information in single neurons in
a "random" fashion, allowing the brain to develop in distinct different ways. Such
strategy contributes to expand the number of functionally distinct neurons that could
be produced from a given stem cell gene pool. This characteristic of variety and flexibility
may contribute to the uniqueness of an individual brain, even between genetically
identical twins. These mobile elements may be part of conserved core process responsible
for evoking facilitated complex non-random phenotypical variation on which selection
may act. A detailed understanding of the basic mechanisms of L1 activity may shed
light on one possible mechanism for generating neural diversity. The book results
from a fascinating and stimulating exchange of ideas at the interface of the complexity
of brain organization and function, the mechanisms for generating diversity and genetic
mobility. This meeting of leading geneticists, molecular biologists and neuroscientists
was organized by the Fondation IPSEN. Its ambitious goal was to expand the current
limits of research in neurobiology not only to the benefit of those interested in
the cellular and molecular processes but also for the understanding of high-level
cognitive functions and the understanding of complex mental diseases. The reader can
judge how far the book achieves this
Autre(s) auteur(s) : Gage, Fred (1950-....). Fonction indéterminée
Sujet(s) : Génétique humaine
Neurosciences
Médecine
Biodiversité
Indice(s) Dewey :
612.8 (23e éd.) = Système nerveux (physiologie humaine)
Identifiants, prix et caractéristiques : ISBN 9783540749660
Identifiant de la notice : ark:/12148/cb44695796x
Notice n° :
FRBNF44695796
(notice reprise d'un réservoir extérieur)
