Notice bibliographique
- Notice
Type(s) de contenu et mode(s) de consultation : Texte noté : électronique
Titre(s) : The Vascular Endothelium I [Texte électronique] / edited by Salvador Moncada, Annie Higgs
Publication : Berlin, Heidelberg : Springer Berlin Heidelberg : Springer e-books, 2006
Description matérielle : 1 online resource
Collection : Handbook of Experimental Pharmacology ; 176/I
Note(s) : It was with great pleasure that I accepted the invitation of Springer to edit thisbook.Myassociationwiththevascularendotheliumcoversalargepartof
myscienti?ccareerand,aswithanygoodlong-standingrelationship,ithas had moments of great
excitement and periods of laborious construction. It hassometimesbeendif?cultbuthasnevergivenmecausefordespondency.
Indeed,inthelastquarterofacentury,researchonthevascularendothelium hasbeenveryproductiveanditsresultshavecontributed,arguablymorethan
any others, to unravelling the mystery of cardiovascular disease, its origin, itsdevelopment,itscomplicationsanditspreventionortreatmentonceithas
developed. IamveryhappythatAnnieHiggsagreedtojoinmeinthistask.Overthe yearswehavecollaboratedcloselyand,asalways,shehasshoulderedthebrunt
oftheworkandhasmadesurethatthingsgetdonetoeverybody'ssatisfaction. We have also been
fortunate in that the scientists who have made some of the most signi?cant contributions
in the ?eld agreed to write chapters; as aresult,wehaveproducedtwovolumeswhichisagoodrepresentationofour
knowledgeinearly2006.Weare,however,awarethatthe?eldhasexpanded beyond all expectation
and that there may have been some oversight in the covering of a speci?c area or some
aspect of it. This is compounded by the speed at which knowledge is being generated,
with more than 4,100 papers concerningtheendotheliumpublishedin2005. Thesevolumesareorganisedinsuchawaythattheearlychaptersdiscussthe
structure,developmentandfunctionofthenormalvascularendothelium.The subsequent chapters
consider conditions that lead to disruption of vascular physiology, while the later
chapters deal with speci?c pathologies and their treatment.The?nalchapterdescribesvariousgene-therapystrategiesforthe
treatmentofvascularpathologies.Interestingly,althoughthis?eldofresearch can now be
considered mature, it continues to generate a great deal of new informationatatimewhensomeofitsfruitsarehavingadirectimpacton
clinical medicine. This is clearly exempli?ed in the contents of most of the chapters.
Theconceptofendothelialdysfunction,althoughmootedmanyyearsago, hascometotheforeandhasbeenveryusefulinde?ningasituationwhichmay
existlongbeforetheovertsignsofvasculardiseasescanbeidenti?ed.Although VI Preface endothelial
dysfunction is likely to comprise a variety of disturbances, it is interesting that
these days it is almost exclusively measured as a decrease innitricoxide(NO)-dependentvasculardilatation,eitherinducedbysuitable
pharmacologicalagonistsorbyincreasesinblood?ow.Oxidativestress,which isassociatedwiththegenesisofendothelialdysfunction,isaloosetermused
tode?neanimbalancebetweenthereleaseofoxygen-derivedfreeradicalsand theanti-oxidantsystemsofthebody.Manyyearsagoourworkestablishedthat
reactiveoxygenspeciesareimportantinreducingthelocalconcentrationsof bothprostacyclin
and NO. It is now clear that free radicals also affect other homeostaticsystemsinthevasculature.However,manythingsremaintobe
clari?ed,especiallytheoriginofoxidativestressinearlydisease
Autre(s) auteur(s) : Moncada, Salvador (1944-....). Éditeur scientifique
Higgs, Annie. Fonction indéterminée
Sujet(s) : Endothélium vasculaire
Indice(s) Dewey :
615 (23e éd.) = Pharmacologie et thérapeutique ; 612.13 (23e éd.) = Vaisseaux sanguins et circulation vasculaire (physiologie humaine)
Identifiants, prix et caractéristiques : ISBN 9783540329671
Voir aussi : Publication alternative dans un autre support/format : The vascular endothelium. 1 [Texte imprimé],
ISBN 3540329668
Identifiant de la notice : ark:/12148/cb446863856
Notice n° :
FRBNF44686385
(notice reprise d'un réservoir extérieur)
