Type(s) de contenu et mode(s) de consultation : Texte noté : électronique

Titre(s) : Lipids in protein misfolding [Texte électronique] / Olga Gursky, editor

Publication : Cham : Springer, cop. 2015

Description matérielle : 1 ressource dématérialisée

Collection : Advances in experimental medicine and biology ; volume 855

Note(s) : Includes bibliographical references and index
"This book addresses molecular mechanisms of protein misfolding and the role of lipids and related molecules in these complex processes. The focus is on the biophysical and structural studies of proteins that are involved in major human disorders such as Alzheimer's disease, systemic amyloidoses, diabetes II, inflammation and atherosclerosis. Misfolding often results from protein mutations or modifications. Misfolding of membrane proteins can cause topological changes that target the proteins for degradation. Misfolding of soluble globular proteins and peptides converts them into [beta]-sheet-rich aggregates and amyloid fibrils. This process can disrupt the structural integrity of the lipid membranes and thereby contribute to amyloid toxicity. In turn, lipids and lipid-associated molecules such as apolipoproteins and heparan sulfate proteoglycans, which are ubiquitous constituents of amyloid plaques, can influence protein misfolding via diverse mechanisms that are addressed in this book. The book features chapters describing the role of lipids in the misfolding of a wide range of proteins, including small peptides, globular proteins, lipid surface-binding proteins, and integral membrane proteins. The role of individual lipid molecules, lipid surfaces, and the membrane field is addressed, including specific and non-specific interactions with protein oligomers and mature fibrils. Distinct effects of various lipids on the nucleation and growth of amyloid fibrils are discussed. Modern computational approaches to the analysis of amyloid formation are addressed. The book should be useful to experts in the field but is also accessible to novices"--Back cover

Autre(s) auteur(s) : Gursky, Olga. Fonction indéterminée  Voir les notices liées en tant qu'auteur

Sujet(s) : Protéines -- Conformation  Voir les notices liées en tant que sujet
Protéines membranaires  Voir les notices liées en tant que sujet
Lipides des membranes  Voir les notices liées en tant que sujet

Indice(s) Dewey :  547 (23e éd.) = Chimie organique  Voir les notices liées en tant que sujet ; 572.633 (23e éd.) = Protéines - Structure moléculaire  Voir les notices liées en tant que sujet

Identifiants, prix et caractéristiques : ISBN 9783319173443

Identifiant de la notice  : ark:/12148/cb44679373q

Notice n° :  FRBNF44679373 (notice reprise d'un réservoir extérieur)

Table des matières : Protein misfolding in lipid-mimetic environments ; Lipids in amyloid-[beta] processing, aggregation, and toxicity ; Role of cholesterol and phospholipids in amylin misfolding, aggregation and etiology of islet amyloidosis ; Intrinsic stability, oligomerization, and amyloidogenicity of HDL-free serum amyloid A ; Interactions of lipid membranes with fibrillar protein aggregates ; The role of lipid in misfolding and amyloid fibril formation by apolipoprotein C-II ; Amyloid-forming properties of human apolipoproteins: sequence analyses and structural insights ; Computational approaches to identification of aggregation sites and the mechanism of amyloid growth ; Role of syndecans in lipid metabolism and human diseases.