Notice bibliographique
- Notice
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001 FRBNF44676861000000X
008 170801s 2014 cheng b 001
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017 .. $o OCoLC $a 882188593 $k NLM $l eng $m BTCTA $m CDX $m OHX $m YDXCP $m OCLCF $m N5L $m OCLCO $m OCLCQ $n rda
020 .. $a 9783319088945
051 .. $a txt $b c
245 1. $a Glutamate and ATP at the interface of metabolism and signaling in the brain $d Texte électronique $f Vladimir Parpura, Arne Schousboe, Alexei Verkhratsky, editors
260 .. $a Cham $c Springer $d [2014]
280 .. $a 1 ressource dématérialisée
295 1. $a Advances in Neurobiology $v volume 11
300 .. $a Includes bibliographical references and index
330 .. $a ATP was naturally selected very early on as the main source of biological energy,
and thus became an indispensable feature of life on the Earth. This was a critical
evolutionary choice because it shaped enzymatic systems to utilize ATP in energy-dependent
reactions and necessitated an appearance of the universal intracellular signaling
system based on calcium ions; keeping cytosolic Ca2+ extremely low became vitally
important, since otherwise insoluble Ca2+-phosphates would preclude the cell energetics.
Thus, all living cells on the Earth, beginning from the most primitive ones, had high
cytosolic concentrations of ATP and there is little surprise that ATP was soon utilized
by nature for another fundamental function of sending information from one living
cell to another. In summary, ATP acts as the main energy source and is pivotal for
numerous signaling cascades both inside (by fueling various transport systems and
donating phosphate groups) and between the cells (by chemical transmission). Similarly,
glutamate acts as an important molecule for both intercellular signaling through glutamatergic
transmission and cell energetics by contributing to ATP production. In this collection
of chapters, written by the leading experts in the fields of cell metabolism and energetics,
intracellular signaling and neurotransmission, we covered various aspects of the interfacing
between these two fundamental molecules. This book will be particularly useful for
researchers, students, physicians and psychotherapists working in the field of neurobiology,
neurology and psychiatry
829 .. $a 1. Glutamate and ATP: The Crossroads of Signaling and Metabolism in the Brain ; 2.
Glutamate Metabolism in the Brain Focusing on Astrocytes ; 3. Glycogenolysis and
Purinergic Signaling ; 4. Purinergic and Glutamatergic Receptors on Astroglia ;
5. Regulated Exocytosis in Astrocytes Is as Slow as the Metabolic Availability of
Gliotransmitters: Focus on Glutamate and ATP ; 6. Adenosine and Glutamate in Neuroglial
Interaction: Implications for Circadian Disorders and Alcoholism ; 7. Purinergic
Receptor Stimulation Decreases Ischemic Brain Damage By Energizing Astrocyte Mitochondria
; 8. Excitotoxicity and Mitochondrial Dysfunction Underlie Age-dependent Ischemic
White Matter Injury ; 9. Role of Astrocytes in Delayed Neuronal Death: GLT-1 and
its Novel Regulation by MicroRNAs ; 10. Ca2+ Signaling in Astrocytes and its Role
in Ischemic Stroke ; 11. Pathological Potential of Astroglial Purinergic Receptors.
