Notice bibliographique
- Notice
Type(s) de contenu et mode(s) de consultation : Texte noté : électronique
Titre(s) : Stem cells and cancer [Texte électronique] / edited by Rebecca G. Bagley, Beverly A. Teicher
Publication : Totowa, N.J. : Humana, cop. 2009
Description matérielle : 1 online resource (xv, 334 pages, [12] pages of plates)
Collection : Cancer drug discovery and development
Note(s) : Includes bibliographical references and index
Significance of Stem Cells to Tumor Development Cancer stem cells remain a controversial
topic and the criteria that define cancer stem cells are continuing to evolve. A recent
surge in stem cell research has ignited a field of discovery into many human diseases
including diabetes, neuropathologies, and cancer. By replacing specific differentiated
cells that have either been lost or died, stem cell therapy proves to be a very promising
approach to the treatment of many debilitating diseases. Though stem cells may provide
therapeutic benefit under certain conditions, they are also often implicated in the
initiation, progression, and therapeutic resistance of malignant disease. This first
edition of Stem Cells and Cancer is intended to give a current perspective on the
role of stem cells in cancer and strategies for novel therapies directed toward tumor
stem cells. The current cancer stem cell hypothesis is presented in several chapters
with distinctions made between the hierarchical and stochastic models of tumor cell
development. "Stemness," self-renewal, pluripotency, clonality, and tumorigenicity
are important concepts applied towards defining cancer stem cells. Signaling pathways
such as Wnt, Sonic Hedgehog, Notch, and Bmi-1 that are involved in differentiation,
proliferation, and survival are implicated in the malignant process. Additional chapters
address the identification of cancer stem cell populations through the evaluation
of molecular markers such as CD133, CD44, and CD24, for example, or by Hoescht dye
exclusion to recognize {u2018}side populations.{u2019} Mesenchymal and hematopoietic
stem cells are described as well as mouse models that are employed to elucidate the
properties and functionality of stem cells in cancer and the stem cell niche. This
book encompasses a wide variety of human cancers that include but are not limited
to leukemia, gliomas, breast, and prostate cancers. Resistance to conventional therapies,
genetic versus epigenetic changes that affect therapeutic response and strategies
to prevent disease recurrence are challenges have been incorporated into this volume.
Stem Cells and Cancer represents a compendium of cutting edge research by experts
in the field and will be instrumental in the study of this intriguing line of investigation
for many years to come. Rebecca Bagley is a senior scientist at Genzyme Corporation
and has worked in the biotechnology industry for 20 years with degrees in biology
from Wellesley College and Harvard University. Her expertise in drug development spans
a wide range of approaches including immunotherapies, gene and protein therapies,
and small molecule delivery with publications in journals such as Molecular Cancer
Therapeutics, Cancer Research, and Microvascular Research . Her current research focuses
on stem cells, tumor vasculature, and target validation. Dr. Beverly A. Teicher is
Vice President of Oncology Research at Genzyme Corporation. Dr. Teicher completed
a PhD in Bioorganic Chemistry at the Johns Hopkins University and postdoctoral training
at Yale University School of Medicine. Dr. Teicher joined Dana-Farber Cancer Institute
as an Assistant Professor of Pathology and rose to Associate Professor of Medicine
and Radiation Therapy, Harvard Medical School at Dana-Farber Cancer Institute and
Joint Center for Radiation Therapy. Dr. Teicher is an active member of the international
scientific community having authored or co-authored more than 400 scientific publications.
She has edited eight books, is senior editor for the journal Clinical Cancer Research
and is series editor for the Cancer Drug Discovery and Development book series
Autre(s) auteur(s) : Bagley, Rebecca G.. Fonction indéterminée
Teicher, Beverly A. (1952-....). Fonction indéterminée
Sujet(s) : Cellules souches
Cellules cancéreuses
Cancer -- Étiologie
Médecine
Sciences de la vie
Indice(s) Dewey :
616.027 74 (23e éd.) = Cellules souches (médecine expérimentale)
Identifiants, prix et caractéristiques : ISBN 9781603279338
Identifiant de la notice : ark:/12148/cb44669319q
Notice n° :
FRBNF44669319
(notice reprise d'un réservoir extérieur)
Table des matières : Introduction to cancer stem cells ; The stem cell niche ; Molecular pathways and
gene expression ; Cancer stem cells in solid tumors ; Targeting cancer stem cells
with therapy.
