Notice bibliographique
- Notice
Type(s) de contenu et mode(s) de consultation : Texte noté : électronique
Titre(s) : Physical basis of bacterial quorum communication [Texte électronique] / Stephen J. Hagen, editor
Publication : New York : Springer, cop. 2015
Description matérielle : 1 ressource dématérialisée
Collection : Biological and medical physics, biomedical engineering
Note(s) : Includes bibliographical references and index
This book aims to educate physical scientists and quantitatively-oriented biologists
on the application of physical experimentation and analysis, together with appropriate
modeling, to understanding and interpreting microbial chemical communication and especially
quorum sensing (QS). Quorum sensing describes a chemical communication behavior that
is nearly universal among bacteria. Individual cells release a diffusible small molecule
(an autoinducer) into their environment. A high concentration of this autoinducer
serves as a signal of high population density, triggering new patterns of gene expression
throughout the population. However QS is often much more complex than simple census-taking.
Many QS bacteria produce and detect multiple autoinducers, which generate quorum signal
cross talk with each other and with other bacterial species. QS gene regulatory networks
operate in physically complex environments and respond to a range of inputs in addition
to autoinducer signals. While many individual QS systems have been characterized in
great molecular and chemical detail, quorum communication raises fundamental quantitative
problems that increasingly attract the attention of physical scientists and mathematicians.
Key questions include: What kinds of information can a bacterium gather about its
environment through QS? How do QS regulatory networks employ feedback and nonlinearity,
and how do they modulate or manage gene regulatory noise? How does QS function in
complex, spatially structured environments such as biofilms? What physical and chemical
factors in the environment ultimately constrain diffusion-based communication? What
types of physical phenomena, such as motility and hysteresis, can be facilitated by
QS? How can we manipulate and interpret QS behavior in complex physical environments
and artificial structures? Previous books and reviews have focused on the microbiology
and biochemistry of QS. With contributions by leading scientists and mathematicians
working in the field of physical biology, this volume examines the interplay of diffusion
and signaling, collective and coupled dynamics of gene regulation, and spatiotemporal
QS phenomena. Chapters describe experimental studies of QS in natural and engineered
or microfabricated bacterial environments, as well as theory and modeling of QS on
intracellular as well as extracellular, macroscopic length scales. · Analyzes bacterial
quorum sensing from a physical and mathematical perspective · Explores the role of
spatiotemporal diffusion, physical environment, regulatory dynamics, stochasticity
and information in quorum communication · Includes contributions from leading experimentalists,
theoreticians, engineers and modelers · Takes a physical science and engineering approach
to the subject, but will appeal to anyone with an interest in physical biology
Autre(s) auteur(s) : Hagen, Stephen J.. Fonction indéterminée
Sujet(s) : Quorum sensing
Transduction du signal cellulaire
Biophysique
Indice(s) Dewey :
571.74 (23e éd.) = Biochimie de la régulation
Identifiants, prix et caractéristiques : ISBN 9781493914029
Identifiant de la notice : ark:/12148/cb44667985p
Notice n° :
FRBNF44667985
(notice reprise d'un réservoir extérieur)
Table des matières : Chapter 1. Introduction ; Chapter 2. Modeling of Signal Transduction by The Quorum-Sensing
Pathway in the Vibrios ; Chapter 3. Stochastic Effects in Quorum Sensing ; Chapter
4. Spatial Structure of Microbes in Nature and the Biophysics of Cell-Cell Communication
; Chapter 5. Functionality of Autoinducer Systems in Complex Environments ; Chapter
6. Localization of Quorum Sensing by Extracellular Polymeric Substances (EPS): Considerations
of in Situ Signaling ; Chapter 7. Swimming in Information? Physics Limits to Learning
by Quorum Sensing ; Chapter 8. Interplay Between Sibling Bacterial Colonies ; Chapter
9. Mathematical Insights Into the Role of Feedback in Quorum-Sensing Architectures
; Chapter 10. The Role of Biosurfactants in Bacterial Systems ; Chapter 11. Ecology
of a Simple Synthetic Biofilm ; Chapter 12. Engineering Cell-to-Cell Communication
To Explore Fundamental Questions in Ecology and Evolution.