Notice bibliographique
- Notice
Type(s) de contenu et mode(s) de consultation : Texte noté : électronique
Titre(s) : Biophysics for therapeutic protein development [Texte électronique] / Linda O. Narhi, editor
Publication : New York : Springer, cop. 2013
Description matérielle : 1 ressource dématérialisée
Collection : Biophysics for the life sciences
Note(s) : Includes bibliographical references and index
This book can be used to provide insight into this important application of biophysics
for those who are planning a career in protein therapeutic development, and for those
outside this area who are interested in understanding it better. The initial chapters
describe the underlying theory, and strengths and weaknesses of the different techniques
commonly used during therapeutic development. The majority of the chapters discuss
the applications of these techniques, including case studies, across the product lifecycle
from early discovery, where the focus is on identifying targets, and screening for
potential drug product candidates, through expression and purification, large scale
production, formulation development, lot-to-lot comparability studies, and commercial
support including investigations
Autre(s) auteur(s) : Narhi, Linda O.. Fonction indéterminée
Sujet(s) : Protéines -- Emploi en thérapeutique
Biophysique
Indice(s) Dewey :
615.19 (23e éd.) = Chimie pharmaceutique
Identifiants, prix et caractéristiques : ISBN 9781461443162
Identifiant de la notice : ark:/12148/cb44665001v
Notice n° :
FRBNF44665001
(notice reprise d'un réservoir extérieur)
Table des matières : Introduction /Linda O. Narhi ; High-Throughput Biophysical Approaches to Therapeutic
Protein Development /Feng He, Vladimir I. Razinkov ; Techniques for Higher-Order Structure
Determination /James Kranz, Fatma AlAzzam, Atul Saluja ; Biophysical Techniques for
Protein Size Distribution Analysis /Ziping Wei, Alla Polozova ; Qualification of Biophysical
Methods for the Analysis of Protein Therapeutics /Yijia Jiang, Cynthia Li, John Gabrielson
; Application of Biophysics to the Early Developability Assessment of Therapeutic
Candidates and Its Application to Enhance Developability Properties /Hasige Sathish,
Nicolas Angell, David Lowe ; Application of Biophysics in Formulation, Process, and
Product Characterization: Selected Case Studies /Satish K. Singh, Qin Zou, Min Huang
; Biophysical Analysis in Support of Development of Protein Pharmaceuticals /Sreedhara
Alavattam, Barthelemy Demeule ; Case Studies Applying Biophysical Techniques to Better
Characterize Protein Aggregates and Particulates o
