Notice bibliographique
- Notice
Type(s) de contenu et mode(s) de consultation : Texte noté : électronique
Titre(s) : Biomedical Informatics for cancer reserach [Texte électronique] / Michael F. Ochs, John T. Casagrande, Ramana V. Davuluri, editors
Publication : New York : Springer, cop. 2010
Description matérielle : 1 ressource dématérialisée
Note(s) : Includes bibliographical references and index
In the past two decades, the large investment in cancer research led to identification
of the complementary roles of genetic mutation and epidenetic change as the fundamental
drivers of cancer. With these discoveries, we now recognize the deep heterogeneity
in cancer, in which phenotypically similar behaviors in tumors arise from different
molecular aberrations. Although most tumors contains many mutations, only a few mutated
genes drive carcinogenesis. For cancer treatment, we must identify and target only
the deleterious subset of aberrant proteins from these mutated genes to maximze efficacy
while minizing harmful side effects. Together, these observations dictate that next-generation
treatments for cancer will become hightly individualized, focusing on the specific
set of aberrant driver proteins identified in a tumor. This drives a need for informatics
in cancer research and treatment far beyond the need in other diseases. For each individual
cancer, we must find the molecular aberrations, identify those that re deleterious
in the specific tumor, design and computationally model treatments, and monitor the
overall health of the individual. This must be done efficiently in order to generate
appropriate treatment plans in a cost-effective manner, State-of-the-art techniques
to address many of these needs are being devloped in biomedical informatics and are
the focus of this volume
Autre(s) auteur(s) : Ochs, Michael F.. Fonction indéterminée
Casagrande, John Thomas (1947-....). Fonction indéterminée
Davuluri, Ramana V.. Fonction indéterminée
Sujet(s) : Cancer -- Thérapeutique
Cancer -- Recherche
Bioinformatique
Identifiants, prix et caractéristiques : ISBN 9781441957146
Identifiant de la notice : ark:/12148/cb446613293
Notice n° :
FRBNF44661329
(notice reprise d'un réservoir extérieur)
Table des matières : Section 1.-- Concepts, issues, and approaches.-- Biomedical informatics for cancer
research: introduction / Michael F. Ochs, John T. Casagrande, Ramana V. Davuluri.--
Clinical research systems and integration with medical systems / Joyce C. Niland,
Layla Rouse.-- Data management, databases, and warehousing / Waqas Amin, Hyunseok
Peter Kang, Michael J. Becich.-- Middleware architecture approaches for collaborative
cancer research / Tahsin Karc, Ashish Sharma, Scott Oster, Tony Pan, Shannon Hastings,
Stephen Langella, David Ervin, Justin Permar, Daniel Brat, T.J. Fitzgerald, James
Purdy, Walter Bosch, Joel Saltz.-- Federated authentication / Frank J. Manion, William
Weems, James McNamee.-- Genomics data analysis pipelines / Michael F. Ochs.-- Mathematical
medeling in cancer / Robert A. Gatenby.-- Reproducible research concepts and tools
for cancer bioinformatics / Vincent J. Carey, Victoria Stodden.-- Cancer biomedical
informatics grid (caBIG[registered trademark]): an evolving commu
Cont.-- Section 2. Tools and applications.-- The caBIG[registered trademark] clinical
trials suite / John Speakman.-- CAISIS research data system / Paul Fearn, Frank Sculli.--
Common applicationframework that is extensible: CAF-E' / Richard Evans, Mark DeTomaso,
Reed Comire, Vaibhav Bora, Jeet Poonater, Aarti Vaishnav, Scott Catherall, John T.
Casagrande.-- Shared resource management / Matt Stine, Vicki Beal, Nilesh Dosooye,
Yingliang Du, Rama Gundapaneni, Andrew Pappas, Srinivas Raghavan, Sundeep Shakya,
Roshan Shrestha, Momodou Sanyang, Clayton Naeve.-- caBIG[registered trademark] life
sciences distribution / Juli Klemm, Anand Basu, Ian Fore, Aris Floratos, George Komatsoulis.--
MeV: multiexperiment viewer / Eleanor Howe, Kristina Holton, Sarita Nair, Daniel Schlauch,
Raktim Sinha, John Quackernbush.-- Authentication and authorization in cancer research
systems / Stephen Langella, Shannon Hastings, Scott Oster, Philip Payne, Frank Siebenlist.--
Caching and visualizing statistical
