Notice bibliographique
- Notice
Type(s) de contenu et mode(s) de consultation : Texte noté : électronique
Titre(s) : Blood-brain barrier in drug discovery [Texte électronique] : optimizing brain exposure of CNS drugs and minimizing brain side effects for peripheral drugs / edited by Li Di, Pharmacokinetics, Dynamics and Metabolism, Pfizer, Inc., Groton, Connecticut, USA, Edward H. Kerns, Laytonsville, MD, USA
Publication : Hoboken, N.J. : John Wiley & Sons Inc., cop. 2015
Description matérielle : 1 ressource dématérialisée
Note(s) : Includes bibliographical references and index
"Focused on central nervous system (CNS) drug discovery efforts, this book educates
drug researchers about the blood-brain barrier (BBB) so they can affect important
improvements in one of the most significant - and most challenging - areas of drug
discovery. Written by world experts to provide practical solutions to increase brain
penetration or minimize CNS side-effects. Reviews state-of-the-art in silico, in vitro,
and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies.
Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis
for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters,
and receptor-mediated processes. Highlights the advances in modelling BBB pharmacokinetics
and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK).
Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths
to the market"
Autre(s) auteur(s) : Di, Li. Fonction indéterminée
Kerns, Edward Harvel. Fonction indéterminée
Sujet(s) : Barrière hématoencéphalique
Système nerveux central
Pharmacie -- Recherche
Indice(s) Dewey :
615.78 (23e éd.) = Médicaments agissant sur le système nerveux
Identifiants, prix et caractéristiques : ISBN 9781118788523
Identifiant de la notice : ark:/12148/cb446551566
Notice n° :
FRBNF44655156
(notice reprise d'un réservoir extérieur)
Table des matières : Introduction and overview / Li Di, and Edward H. Kerns ; Part 1: Pharmacokinetics
of brain exposure. Pharmacokinetics of CNS penetration / Andreas Reichel ; Free drug
hypothesis for CNS drug candidates / Xingrong Liu and Cuiping Chen ; Species differences
and impact of disease state on BBB / Jean-Marie Nicolas ; Part 2: Mechanisms of drugs
across the blood-brain barrier. Passive diffusion permeability of the BBB: examples
and SAR / Scott Summerfield, Phil Jeffrey, Jasminder Sahi, and Liangfu Chen ; Efflux
transport at the BBB: examples and SAR / Jerome Hochman ; Establishment of P-glycoprotein
structure-transport relationships to optimize CNS exposure in drug discovery / Jerome
H. Hochman, Sookhee N. Ha, and Robert P. Sheridan ; Uptake transport at the BBB:
examples and SAR / Ziquiang Cheng and Qian Liu ; Transport of protein and antibody
therapeutics across the blood-brain barrier / William M. Pardridge ; Part 3: Predicting
and measuring brain exposure of drugs. In silico
