Notice bibliographique
- Notice
000 nam 22 3 450
001 FRBNF446547370000002
010 .. $a 9781118695920
035 .. $a OCoLC893202820
100 .. $a 20170801d2015 m y0engy50 ba
101 1. $a eng $c rus
102 .. $a GB
105 .. $a y z 00|y|
106 .. $a s $a z
135 .. $a dru||||||||||
181 .0 $6 01 $a i $b xxxe
181 .. $6 02 $c txt $2 rdacontent
182 .0 $6 01 $a b
182 .. $6 02 $c c $2 rdamedia
200 1. $a Hyaluronic acid $b Texte électronique $e preparation, properties, application in biology and medicine $f V.N. Khabarov, P. Ya. Boykov and M.A. Selyanin $g translated from the Russian by scientific editor Dr. F. Polyak
210 .. $a Chichester, West Sussex $c John Wiley & Sons, Ltd. $d 2015
215 .. $a 1 online resource
300 .. $a Includes bibliographical references and index
300 .. $a Print version record and CIP data provided by publisher.
330 .. $a Hyaluronic acid is an essential part of connective, epithelialand neural tissues,
and contributes to cell proliferation andmigration. It is used as a stimulating agent
for collagen synthesisand is a common ingredient in skin-care products, a multi-billiondollar
industry, as it is believed to be a key factor in fightingthe aging process. Hyaluronic
Acid: Production, Properties, Application inBiology and Medicine consists of six chapters
discussing thevarious issues of hyaluronic acid research. In Chapter 1, ahistorical
analysis recounts the discovery and milestones of theresearch leading to the practical
applications of hyaluronan. Chapter 2 is dedicated to biological role of the hyaluronic
acid innature, in particular in the human body. The chapter starts fromthe phylogenesis
of hyaluronic acid, then describes hyaluronanfunctions in human ontogenesis and especially
the role whichhyaluronan plays in extracellular matrix of the different tissues. Chapter
3 describes the methods to manufacture and purifyhyaluronic acid, including the analytical
means for assessingquality of the finished product. Chapter 4 discusses the structureand
rheological properties of hyaluronic acid considering effectson conformation and biological
properties related to molecularweight. In Chapter 5, the physical and chemical methods
formodifying the structure of hyaluronan are discussed includingcross-linking using
bi-functional reagents, solid-phasemodification and effects of the combined action
of high pressuresand shift deformation. The final chapter focuses on the productsderived
from hyaluronic acid, including therapeutics composed ofmodified hyaluronan conjugated
to vitamins, amino acids andoligo-peptides. The biological roles and medical applications
ofthis polysaccharide have been extensively studied and this bookprovides a wealth
of scientific data demonstrating the criticalrole of hyaluronic acid and its promise
as a multifacetedbio-macromolecule. Approaching hyaluronic acid from multiple angles,
this booklinks relationships between its biological functions, structure andphysical'chemical
properties. It will be an invaluableresource to researchers, both industrial and academic,
involved inall aspects of hyaluronan-based technologies
801 .3 $a US $b OCoLC $c 20170801 $h 893202820 $2 marc21
801 .0 $b DLC $g rda ; pn
930 .. $5 FR-759999999:44654737001001 $a ACQNUM-36503 $b 759999999 $c Document numérisé $d N
