Notice bibliographique
- Notice
Type(s) de contenu et mode(s) de consultation : Texte noté : électronique
Auteur(s) : Thevis, Mario (1973-....)
Titre(s) : Mass spectrometry in sports drug testing [Texte électronique] : characterization of prohibited substances and doping control analytical assays / Mario Thevis
Publication : Hoboken, N.J. : Wiley, cop. 2010
Description matérielle : 1 online resource (xiii, 360 pages)
Collection : Wiley-Interscience series in mass spectrometry
Note(s) : Includes bibliographical references and index. - Print version record.
"This book provides a detailed overview about the mass spectrometry of numerous classes
of therapeutics and agents relevant to doping control laboratories, the necessity
of various analyzers enabling the detection of low- and high molecular weight drugs
as well as the discrimination between endogenously produced and synthetically derived
compounds. Typical assays including sample preparation, chromatographic separation
and mass spectrometric analysis are presented highlighting the comprehensiveness of
drug testing in modern doping control laboratories"--Provided by publisher
Sujet(s) : Spectrométrie de masse
Médicaments -- Analyse
Dopage dans les sports
Spectroscopie
Genre ou forme : Méthodes (musique)
Indice(s) Dewey :
362.29 (23e éd.) = Toxicomanie
Identifiants, prix et caractéristiques : ISBN 9780470626634
Identifiant de la notice : ark:/12148/cb446494334
Notice n° :
FRBNF44649433
(notice reprise d'un réservoir extérieur)
Table des matières : History of sports drug testing ; Historical attempts of artificial performance enhancement
; Background and rationale of doping controls ; Cheating ; Health issues ; Ethical
issues ; Early detection methods: possibilities and limitations of assays without
mass spectrometry ; First applications using chemical and biological approaches in
horse doping control ; First applications using chemical and biological approaches
in horse doping control ; First applications using chemical approaches in human doping
control ; Introduction of mass spectrometry to doping control analysis ; First approaches
and adverse analytical findings ; Progressino of analytical methods ; Mass spectrometry
and the list of prohibited substances and methods of doping ; Criteria for the mass
spectrometric identification of prohibited compounds ; Low molecular weight analytes
; High molecular weight analytes ; Modern mass spectrometers in doping controls:
advances and disadvantates of available tec
Structure characterization of high molecular weight target analytes: electrospray
ionization ; Human chorionic gonadotrophin (hCG) ; Erythropoietins (EPO) ; Synacthen
; Insulins ; Hemoglobin-based oxygen carriers (HBOCs) ; Human growth hormone (hGH)
; Sermorelin (Geref) ; Insulin-like growth factor-1 (IGF-1) ; Gonadorelin (LHRH)
; Modern mass spectrometry-based analytical assays ; GC-MS and isotope ratio mass
spectrometry ; Stimulants/narcotics ; Anabolic androgenic steroids ; Diuretics
; ß₂-agonists and ß-receptor blocking agents ; Carbohydrate-based agents ; LC-MS/MS
; Stimulants/narcotics/ß₂-agonists/ß-receptor blocking agents ; Anabolic androgenic
steroids/corticosteroids/hormone antagonists and modulators ; Masking agents (including
diuretics) ; Peptide hormones <10kDa including insulins, synacthen, gonadorelin,
IGF-1 ; Hemoglobin-based oxygen carriers ; Human chorionic gonadotrophin (hCG) ;
Limitations and perspectives of mass spectrometry-based
