Notice bibliographique
- Notice
Type(s) de contenu et mode(s) de consultation : Texte noté : électronique
Titre(s) : The local cardiac renin angiotensin-aldosterone system [Texte électronique] / edited by Edward D. Frohlich and Richard N. Re.
Publication : New York : Springer, cop. 2006
Description matérielle : 1 online resource (xvi, 224 pages)
Collection : Basic science for the cardiologist ; 20
Note(s) : Includes bibliographical references and index. - Print version record.
How exciting it is to see a field so well established as the ren- angiotensin system
continue to grow and mature. Originally, following the original identification of
renin by Tigerstedt and Bergman over 100 years ago, workers in this area spent years
attempting to establish its role in experimental and renal hypertension. The early
work by Goldblatt, in 1934, demonstrated that the placement of a clip around a renal
artery was clearly related to the subsequent development of hypertension. However,
it wasn't until the simultaneous finding by two different geographically separated
teams, Page, et al, in the United States and Braun-Menendez, et al, in Argentina that
the peptide angiotensin was identified. Thus, the rate-limiting enzyme renin was released
from the kidney and catalyzed a biochemical cascade which was eventually shown to
produce the elevated arterial pressure. Subsequently, many workers contributed to
the elucidation of the concept and sequence of angiotensin I1 generation. Thus, the
enzyme renin acted upon its protein substrate, produced in the liver, to liberate
the decapeptide angiotensin I which, upon circulating through the pulmonary circulation,
finally produced the potent octapeptide angiotensin. Several important subsequent
findings demonstrated that angiotensin I1 promoted the release of the adrenal corticosteroid
from that gland, thereby resulting in a larger system, the renin-angiotensin-aldosterone
system. Further, this system demonstrated a classical biofeedback and the circulating
octapeptide was shown to have additional biological activities in organs other than
heart, vessels, kidney, adrenals, and even brain
Autre(s) auteur(s) : Frohlich, Edward D. (1931-....). Fonction indéterminée
Re, Richard Noel. Fonction indéterminée
Sujet(s) : Système rénine-angiotensine
Hypertension rénale
Rénine
Indice(s) Dewey :
612.17 (23e éd.) = Coeur (physiologie humaine)
Identifiants, prix et caractéristiques : ISBN 9780387278261
Identifiant de la notice : ark:/12148/cb446418339
Notice n° :
FRBNF44641833
(notice reprise d'un réservoir extérieur)
Table des matières : Preface / Edward D. Frohlich, Richard N. Re ; Hypertensive heart disease : time for
new paradigms / Edward D. Frohlich ; Cardiac (PRO) renin receptors : functional properties
and potential significance / Genevieve Nguyen, A.H. Jan Danser ; On the relationship
between the renin receptor and the vacuolar proton-ATPase membrane sector-associated
protein (M8-9) / Nathalie L'Huillier [and others] ; Role of the AT₂ receptor in cardiovascular
function : a brief synopsis / Robert M. Carey, Helmy M. Siragy ; Reciprocal regulation
of renin in JGA and tubules in hypertension / L. Gabriel Navar [and others] ; Salt
loading a paradigm for a local cardiac renin-angiotensin-aldosterone System / Jasmina
Varagic ; Lessons from experimental generation of intracellular angiotensinogen and
A11 / Julia L. Cook, Richard N. Re ; On the cardiac renin angiotensin system : the
heart as a source of angiotensin II / Walmor C. De Mello ; The hematopoietic system
: a new niche for the renin-angiotens
