Notice bibliographique
- Notice
Type(s) de contenu et mode(s) de consultation : Texte noté : électronique
Auteur(s) : Ivanovic, Zoran (1963-....)
Vlaski-Lafarge, Marija
Titre(s) : Anaerobiosis and stemness [Texte électronique] : an evolutionary paradigm / Zoran Ivanovic, Marija Vlaski-Lafarge
Publication : Amsterdam : Elsevier/Academic Press, [2016]
Description matérielle : 1 ressource dématérialisée
Note(s) : Includes bibliographical references and index
"Anaerobiosis and Stemness: An evolutionary paradigm provides a context for understanding
the many complexities and evolutionary features of stem cells and the clinical implications
of anaerobiosis stem cells. Combining theoretical and experimental knowledge, the
authors provide a broad understanding of how the absence or low concentration of oxygen
can play an influential role in the maintenance and self-renewal of stem cells and
stem cell differentiation. This understanding has clinical implications for the fields
of regenerative medicine, cancer biology and transplantation, as well as cell engineering
and cell therapy. Anaerobiosis and Stemness is an important resource for stem cell
and developmental biologists alike, as well as oncologists, cancer biologists, and
researchers using stem cells for regeneration."--Page 4 of cover
Sujet(s) : Cellules souches
Anaérobiose
Différenciation cellulaire
Cellules souches -- Recherche
Anaérobiose -- Recherche
Cellules souches -- Emploi en thérapeutique
Anaérobiose -- Emploi en thérapeutique
Indice(s) Dewey :
572.478 (23e éd.) = Respiration anaérobie
Identifiants, prix et caractéristiques : ISBN 9780128005408
Identifiant de la notice : ark:/12148/cb446398033
Notice n° :
FRBNF44639803
(notice reprise d'un réservoir extérieur)
Table des matières : Introduction : special remarks ; What entity could be called a stem cell? ; In situ
Normoxia versus "hypoxia" ; Part 1. Anaerobiosis and stem cell entity. The "hypoxic"
stem cell niche ; Low O2 concentrations and the maintenance of stem cells ex vivo
; Quiescence/proliferation issue and stem cell niche ; Metabolic peculiarities of
the stem cell entity : energetic metabolism and oxidative status ; Molecular basis
of "hypoxic" signaling, quiescence, self-renewal, and differentiation in stem cells
; Part 2. Anaerobic-to-aerobic eukaryote evolution : a paradigm for stem cell self-renewal,
commitment and differentiation?. Evolution of eukaryotes with respect to atmosphere
oxygen appearance and rise : anaerobiosis, facultative aerobiosis, and aerobiosis
; Evolution of mitochondria in eukaryotes versus mitochondria "maturing" from the
stage of stem cells to committed progenitors and mature cells ; Evolutionary origins
of stemness : relationship between self-renewal and ancestral