Notice bibliographique
- Notice
Type(s) de contenu et mode(s) de consultation : Texte noté : électronique
Titre(s) : Hyaluronan in cancer biology [Texte électronique] / edited by Robert Stern
Édition : 1st ed.
Publication : San Diego, CA : Academic Press/Elsevier, 2009
Description matérielle : 1 online resource (xxvii, 426 pages, [12] pages of plates)
Note(s) : Includes bibliographical references and index
Hyaluronan biology is being recognized as an important regulator of cancer progression.
Paradoxically, both hyaluronan (HA) and hyaluronidases, the enzymes that eliminate
HA, have also been correlated with cancer progression. Hyaluronan, a long-chain polymer
of the extracellular matrix, opens up tissue spaces through which cancer cells move
and metastasize. It also confers motility upon cells through interactions of cell-surface
HA with the cytoskeleton. Embryonic cells in the process of movement and proliferation
use the same strategy. It is an example of how cancer cells have commandeered normal
cellular processes for their own survival and spread. There are also parallels between
cancer and wound healing, cancer occasionally being defined as a wound that does not
heal. The growing body of literature regarding this topic has recently progressed
from describing the association of hyaluronan and hyaluronidase expression associated
with different cancers, to understanding the mechanisms that drive tumor cell activation,
proliferation, drug resistance, etc. No one source, however, discusses hyaluronan
synthesis and catabolism, as well as the factors that regulate the balance. This book
offers a comprehensive summary and cutting-edge insight into Hyaluronan biology, the
role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA
synthesis enzymes and their relationship to cancer. Offers a comprehensive summary
and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the
hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship
to cancer. Chapters are written by the leading international authorities on this subject,
from laboratories that focus on the investigation of hyaluronan in cancer initiation,
progression, and dissemination
Autre(s) auteur(s) : Stern, Robert (M.D.). Fonction indéterminée
Sujet(s) : Hyaluronique, Acide -- Physiopathologie
Cancérogenèse
Hyaluronique, Acide -- Métabolisme
Hyaluronique, Acide -- Emploi en thérapeutique
Indice(s) Dewey :
616.994 071 (23e éd.) = Cancers (médecine) - Étiologie
Identifiants, prix et caractéristiques : ISBN 9780123741783
Identifiant de la notice : ark:/12148/cb44633842j
Notice n° :
FRBNF44633842
(notice reprise d'un réservoir extérieur)
Table des matières : Association between cancer and "acid mucopolysaccharides" : an old concept comes of
age, finally ; Hyaluronan-CD44 interactions and chemoresistance in cancer cells ;
Growth factor regulation of hyaluronan deposition in malignancies ; Hyaluronan binding
protein 1 (HABP1/p32/gClqR) : a new perspective in tumor development ; CD44 meets
Merlin and Ezrin : their interplay mediates the pro-tumor activity of CD44 and tumor-suppressing
effect of Merlin ; Hyaluronan-mediated CD44 interaction with receptor and non-receptor
kinases promotes oncogenic signaling, cytoskeleton activation, and tumor progression
; Adhesion and penetration : two sides of CD44 signal transduction cascades in the
context of cancer cell metastasis ; Involvement of CD44, a molecule with a thousand
faces, in cancer dissemination ; RHAMM/HMMR : an itinerant and multifunctional hyaluronan
binding protein that modifies CD44 signaling and mitotic spindle formation ; Altered
hyaluronan biosynthesis in cancer progress
Hyaluronidase : both a tumor promoter and suppressor ; The hyaluronidases in cancer
biology ; Hyaluronan fragments : informational polymers commandeered by cancers ;
Hyaluronan in human tumors : importance of stromal and cancer cell-associated hyaluronan
; The oncofetal paradigm revisited : MSF and HA as contextual drivers of cancer progression
; Hyaluronan synthesis and turnover in prostate cancer ; Role of hyaluronan in melanoma
progression ; Role of hyaluronan metabolism in the initiation, invasion, and metastasis
of breast cancer ; Clinical use of hyaluronidase in combination cancer chemotherapy
: a historic perspective ; Exploring the hyaluronan:CD44 interaction for cancer therapy
; Hyaluronidase-2 and its role as a cell-entry receptor for sheep retroviruses that
cause contagious respiratory tract cancers.
