Type(s) de contenu et mode(s) de consultation : Texte noté : électronique

Titre(s) : Endoplasmic reticulum stress in health and disease [Texte électronique] / Patrizia Agostinis, Afshin Samali, (eds)

Publication : Dordrecht : Springer, cop. 2012

Description matérielle : 1 ressource dématérialisée

Note(s) : Includes bibliographical references and index
The Endoplasmic Reticulum (ER) is an organelle with extraordinary signaling and homeostatic functions. It is the organelle responsible for protein folding, maturation, quality control and trafficking of proteins destined for the plasma membrane or for secretion into the extracellular environment. Failure, overloading or malfunctioning of any of the signaling or quality control mechanisms occurring in the ER may provoke a stress condition known as âER stressâ. Accumulating evidence indicates that ER stress may dramatically perturb interactions between the cell and its environment, and contribute to the development of human diseases, ranging from metabolic diseases and cancer to neurodegenerative diseases, or impact therapeutic outcome. This book primarily focuses on the pathophysiology of ER stress. It introduces the molecular bases of ER stress, the emerging relevance of the ER-mitochondria cross-talk, the signaling pathways engaged and cellular responses to ER stress, including the adaptive Unfolded Protein Response (UPR), autophagy as well as cell death. Next the book addresses the role of ER stress in physiology and in the etiology of relevant pathological conditions, like carcinogenesis and inflammation, neurodegeneration and metabolic disease. The last chapter describes how ER stress pathways can be targeted for therapeutic benefit. Altogether, this book will provide the reader with an exhaustive view of ER stress biology and the latest insights in the role of ER stress in relevant human diseases

Autre(s) auteur(s) : Agostinis, Patrizia. Fonction indéterminée  Voir les notices liées en tant qu'auteur
Samali, Afshin. Fonction indéterminée  Voir les notices liées en tant qu'auteur

Sujet(s) : Réticulum endoplasmique -- Physiopathologie  Voir les notices liées en tant que sujet
Transduction du signal cellulaire  Voir les notices liées en tant que sujet

Indice(s) Dewey :  571.65 (23e éd.) = Cytoplasme (biologie cellulaire)  Voir les notices liées en tant que sujet

Identifiants, prix et caractéristiques : ISBN 9789400743519

Identifiant de la notice  : ark:/12148/cb447216027

Notice n° :  FRBNF44721602 (notice reprise d'un réservoir extérieur)

Table des matières : Biology of the endoplasmic reticulum / Sandra J.M. Healy, Tom Verfaillie, Richard Jäger, Patrizia Agnostinis and Afshin Samali ; A tight-knit group: protein glycosylation, endoplasmic reticulum stress and the unfolded protein response / Jared Q. Gerlach, Shashank Sharma, Kirk J. Leister and Lokesh Joshi ; ER stress signaling pathways in cell survival and death / Tom Verfaillie, Richard Jäger, Afshin Samali ; Endoplasmic reticulum-mitochondria connections, calcium cross-talk and cell fate: a closer inspection / Riccardo Filadi, Enrico Zampese, Tullio Pozzan, Paola Pizzo and Cristina Fasolato ; ER stress and UPR through dysregulated EF Ca² homeostasis and signaling / Tim Vervliet, Santeri Kiviluoto and Geert Bultynck ; Regulation of ER stress responses by micro RNA's / Danielle E. Read, Ananya Grupta, Karen Cawley and Sanjeev Gupta ; ER stress as modulator of autophagy pathways / Maria Salazar, Sonia Hernábdez-Tiedra, Mar Lorente and Guillermo Velasco ; Physiological ER stress: