Notice bibliographique
- Notice
Type(s) de contenu et mode(s) de consultation : Texte noté : électronique
Titre(s) : Endoplasmic reticulum stress in health and disease [Texte électronique] / Patrizia Agostinis, Afshin Samali, (eds)
Publication : Dordrecht : Springer, cop. 2012
Description matérielle : 1 ressource dématérialisée
Note(s) : Includes bibliographical references and index
The Endoplasmic Reticulum (ER) is an organelle with extraordinary signaling and homeostatic
functions. It is the organelle responsible for protein folding, maturation, quality
control and trafficking of proteins destined for the plasma membrane or for secretion
into the extracellular environment. Failure, overloading or malfunctioning of any
of the signaling or quality control mechanisms occurring in the ER may provoke a stress
condition known as âER stressâ. Accumulating evidence indicates that ER stress may
dramatically perturb interactions between the cell and its environment, and contribute
to the development of human diseases, ranging from metabolic diseases and cancer to
neurodegenerative diseases, or impact therapeutic outcome. This book primarily focuses
on the pathophysiology of ER stress. It introduces the molecular bases of ER stress,
the emerging relevance of the ER-mitochondria cross-talk, the signaling pathways engaged
and cellular responses to ER stress, including the adaptive Unfolded Protein Response
(UPR), autophagy as well as cell death. Next the book addresses the role of ER stress
in physiology and in the etiology of relevant pathological conditions, like carcinogenesis
and inflammation, neurodegeneration and metabolic disease. The last chapter describes
how ER stress pathways can be targeted for therapeutic benefit. Altogether, this book
will provide the reader with an exhaustive view of ER stress biology and the latest
insights in the role of ER stress in relevant human diseases
Autre(s) auteur(s) : Agostinis, Patrizia. Fonction indéterminée
Samali, Afshin. Fonction indéterminée
Sujet(s) : Réticulum endoplasmique -- Physiopathologie
Transduction du signal cellulaire
Indice(s) Dewey :
571.65 (23e éd.) = Cytoplasme (biologie cellulaire)
Identifiants, prix et caractéristiques : ISBN 9789400743519
Identifiant de la notice : ark:/12148/cb447216027
Notice n° :
FRBNF44721602
(notice reprise d'un réservoir extérieur)
Table des matières : Biology of the endoplasmic reticulum / Sandra J.M. Healy, Tom Verfaillie, Richard
Jäger, Patrizia Agnostinis and Afshin Samali ; A tight-knit group: protein glycosylation,
endoplasmic reticulum stress and the unfolded protein response / Jared Q. Gerlach,
Shashank Sharma, Kirk J. Leister and Lokesh Joshi ; ER stress signaling pathways
in cell survival and death / Tom Verfaillie, Richard Jäger, Afshin Samali ; Endoplasmic
reticulum-mitochondria connections, calcium cross-talk and cell fate: a closer inspection
/ Riccardo Filadi, Enrico Zampese, Tullio Pozzan, Paola Pizzo and Cristina Fasolato
; ER stress and UPR through dysregulated EF Ca² homeostasis and signaling / Tim Vervliet,
Santeri Kiviluoto and Geert Bultynck ; Regulation of ER stress responses by micro
RNA's / Danielle E. Read, Ananya Grupta, Karen Cawley and Sanjeev Gupta ; ER stress
as modulator of autophagy pathways / Maria Salazar, Sonia Hernábdez-Tiedra, Mar Lorente
and Guillermo Velasco ; Physiological ER stress: