Notice bibliographique
- Notice
Type(s) de contenu et mode(s) de consultation : Texte noté : électronique
Titre(s) : Novel chemical tools to study ion channel biology [Texte électronique] / Christopher Ahern, Stephan Pless, editors
Publication : New York : Springer, cop. 2015
Description matérielle : 1 ressource dématérialisée
Collection : Advances in experimental medicine and biology ; volume 869
Note(s) : Includes bibliographical references and index
"This volume describes chemical approaches to assess ion channel structure, function
and pharmacology. Topics discussed include the use of engineered ionizable side chains
to obtain information on permeation pathways and the local environment; the modification
of engineered cysteine side chains, including cysteine scanning mutagenesis and the
attachment of fluorescent probes and bio-reactive tethers; and the nascent use of
genetic code expansion, evaluating its applications to ion channel and membrane proteins.
This comprehensive text provides multifaceted perspectives on the great diversity
of state-of-the-art methods which take advantage of the ever-expanding chemical toolbox
to study ion channel biology. Capturing the contributions and innovations of renowned
laboratory researchers in transmembrane protein study for the first time, this book
is comprehensive in scope. It covers a wide array of experimental approaches: photochemistry,
novel biological tools, and innovative spectroscopy, all combined with traditional
techniques of electrophysiology and molecular biology. Novel Chemical Tools to Study
Ion Channel Biology, part of the bestselling Advances in Experimental Medicine and
Biology series is ideal for researchers and advanced students interested in biochemistry,
biophysics, fluorometry, electrophysiology, and chemical biology"--Back cover
Autre(s) auteur(s) : Ahern, Christopher. Fonction indéterminée
Pless, Stephan. Fonction indéterminée
Sujet(s) : Canaux ioniques -- Génétique
Canaux ioniques -- Métabolisme
Canaux ioniques -- Physiologie
Indice(s) Dewey :
571.64 (23e éd.) = Membranes
Identifiants, prix et caractéristiques : ISBN 9781493928453
Identifiant de la notice : ark:/12148/cb446682730
Notice n° :
FRBNF44668273
(notice reprise d'un réservoir extérieur)
Table des matières : Introduction / Stephan A. Pless, Christopher A. Ahern ; Engineered ionizable side
chains / Gisela D. Cymes, Claudio Grosman ; Cysteine modification: probing channel
structure, function and conformational change / Myles H. Akabas ; Functional site-directed
fluorometry / Michael Priest, Francisco Bezanilla ; Bioreactive tethers / Karen Mruk,
William R. Kobertz ; Flipping the photoswitch: ion channels under light control /
Catherine K. McKenzie, Inmaculada Sanchez-Romero, Harald Janovjak ; Incorporation
of non-canonical amino acids / Lilia Leisle, Francis Valiyaveetil, Ryan A. Mehl, Christopher
A. Ahern.